2, 1755 1775 Private in Glover's Twenty-first Regiment, Capt. 1804 Schooner "Betsy" JOHN ROADS RUSSELL Bpt. 8, 1769 1790 Schooner "Samuel" JOHN RUSSELL, 3d. JShip "Tartar" Ship "Edward" Ship "William Goddard" Barque "Rocket" Arrived at Marblehead Ship "Bonetia," Capt. 12, 1777 1790 Schooner "Tabby" 72T 1792 Schooner "Deborah" 1794 Schooner "Polly" 63T 1795 Ship "Hope" 189T JOHN ABBOT RUSSELL Bpt. ROUNDEY 1834 Schooner "Fredonia" 89T 78ĪLEXANDER ROSS Bpt. 1796 Schooner "Richard and Edward" 64T 1801 Schooner "Industry" 86T STEPHEN C. Dated in Marblehead May 27th, 1751 Michael Wormstead JOHN ROUNDEY Born 1803 Brig "Union," 110T. In witness whereof, the Master or Purser of the said Scuner hath affirmed to this Bill of Lading, of this Tenor and Date, One of which Bills being accomplished, the other to stand Void And so God send the good Scuner to her desired Port in Safety. We give below, two floating relics of "good Old Colony Times," which have escaped from the finger of decay, and passed into the hands of the printer :- Shipped by the Grace of God, in good Order and well Conditioned, by John Russell Salor in and upon the good Scuner called, "The Swallow" whereof is Master under God for this present Voyage, John Roundey and now Riding at Anchor in the Harbor of Marblehead and by God's Grace bound for the island of Barbados To say, one Hogset of JeineIR co cood fish containing Seven Quentels and a Half for which fish i promis to Bring in the produse of ye Island Being NJ Marked and Numbered as in the Margent, and are to be delivered in the like good Order and well Conditioned, at the aforesaid Port of Barbados (the Danger of the Seas only excepted) unto Mickel Wormstead or to his Assigns, he or they paying Freight for the said Goods, a pistole with Primage and Average accustomed. 1743 Schooner "Salem" 1751 Schooner "Swallow" (R Hoopers Letter Book) ADVOCATE AND MERCURY Marblehead, Mass, Saturday, January 4, 1850. 7, 1804 1836 Schooner "Mechanic" 53T 1836 Schooner "Teazer" 97T JOHN ROUNDEY Bpt. Henceforth, we sought to: 1) compare diagnostic performance and safety of AMP-BPT and His-BPT in different asthma control levels 2) determine the association between airway responsiveness and asthmatic symptom scores.Ĭurrently, His-BPT is recommended by the Chinese guideline and shares considerable similarity with methacholine (another conventional stimulus) BPT, we therefore did not perform the latter in this study.WILLIAM ROADS Bpt. ![]() responders of AMP-BPT) was associated with significant symptom alleviation. We hypothesized that asthmatic patients, regardless of control levels, responded differentially to AMP-BPT and His-BPT, and that greater reduction in airway responsiveness to AMP (esp. However, differences of response to AMP-BPT and His-BPT in different asthma control levels and their associations with asthmatic symptom scores have not been fully elucidated. Compared with histamine, AMP may be pathophysiologically more relevant to airway inflammation and hyperresponsiveness and has been linked to presence and magnitude of atopy. Additionally, mild adverse events (flushing and hoarseness) and insufficient capacity of identifying exercise-induced asthma have hampered further clinical applications.Īdenosine monophosphate (AMP) is an inflammatory mediator that serves as an indirect bronchial stimulus for detecting airway hyperresponsiveness in asthma. Clinically, histamine BPT (His-BPT) has gained extensive application for decades owing to the assay sensitivity and feasibility, but could not ideally predict anti-inflammatory treatment outcomes in practice. Histamine has been a direct stimulus for inducing bronchoconstriction via vasodilation, eosinophil chemotaxis and tissue edema. Condition or diseaseĭrug: inhaled corticosteroids (usually budesonide/fomorterol 160/4.5mcg fluticasone/salmeterol 250/50mcg)Īirway hyperresponsiveness, the pivotal feature of asthma, can be assessed by bronchial provocation tests (BPTs), which may elicit bronchoconstriction via inhalation of stimuli. Patients with uncontrolled and partly controlled asthma, who maintained their original inhaled corticosteroids therapy, underwent reassessment of airway responsiveness and asthmatic symptoms 3 and 6 months after. Patients with PD20FEV1 lower than geometric mean were defined as responders, otherwise poor responders. ![]() Cumulative doses eliciting 20% FEV1fall (PD20FEV1), diagnostic performance and adverse events were compared. The investigators aimed to compare both BPTs and determine their usefulness in reflecting changes of asthmatic symptoms.īPTs were performed in cross-over fashion, at 2-4day intervals.
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